Lluis Montoliu (Octubre 2015) - Fotografia: Ines Poveda (CNB) WEB of the laboratory of

Dr. Lluís Montoliu

Research Scientist CSIC

Departament of Molecular and Cellular Biology

National Centre of Biotechnology (CNB-CSIC)

Campus de Cantoblanco, C/ Darwin 3

28049 Madrid, Spain

 

Tel. +34 91 585-4844 (office) / +34 91 585-4530 (laboratory)

Fax. +34 91 585-4506 / skype: lluis.montoliu / Twitter: @LluisMontoliu / also in Facebook and LinkedIn

e-mail: montoliu@cnb.csic.es                



 

 

 


 

 

 

Spanish Laws on Bioethics

 

 

 

EMMA

 

European Commission (7FP-Infrastructures)

 

European Society for Pigment Cell Research

 

IFPCS

 

 

 

 

TRANSGENESIS IN SPAIN

Updated March 2015

 

INFRAFRONTIER

 

 

There is no future without Research

 


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Neurosensorial pathology (Group U756) - Coordinator


Research Group:

Animal Models by Genetic Manipulation



 

Research Summary

We are interested in understanding how mammalian expression domains work and how they are organised within genomes. We would like to know the required regulatory elements that identify a given expression domain and specify its expression pattern in space, time and level, to improve the dessign of gene transfer strategies, used for animal transgenesis and for gene therapy.

We use two experimental models: the mouse tyrosinase and whey acidic protein genes, two independent developmentally regulated and tissue-specific loci that have served us to identify a number of key regulatory elements, including boundaries and LCRs. We address our experiments in vivo, using transgenic mice carrying large chromosomal- type constructs that we engineer by homologous recombination to investigate the functional role of specific sequences, and in vitro, using cells and chromatin DNA-protein analyses.

 

Further, our laboratory generates and analyses new animal models of human diseases by genetic modification of mice. We have used a number of tyrosinase transgenic mice to address the retinal deficits commonly associated with albinism, the normal mammalian retinal development and the genes involved in the process. Finally, through collaborations, we have a number of additional animal models (transgenics and knockouts) for CNS-related diseases or conditions (Alzheimer, pain, psychosis).

 

From January 1, 2009, CNB has become the Spanish node of the European Project EMMA.

 


Lluis Montoliu 2015 Curriculum Vitae Lluís Montoliu (January 2017)

 

 Scientific Career

 Scientific Interests

 Current Projects


Browse publications by Lluís Montoliu

 

 

PubMed Central (NIH-free archive of publications)

 

 

Digital Repository CSIC

 


Annual research reports CNB

Dr. Lluís Montoliu's Laboratory

2001-2002

2003-2004

2005-2006

2007-2008

2009-2010

2011-2012

2013-2014

 

 

(PDF documents)


 

Genetic differences among C57BL/6 substrains


 

ACCESS

to the private zone of this WEB

 


 


Molecular Biosciences (UAM)

Course 2016-2017

 

Master in "Molecular Biomedicine"

 

Module BMM11: Genetically Modified Animals: Strategies and applications

Program Course 2016-2017

19 September - 28 October 2016

 

Previous post-graduate courses (1998-2016)

Bioinformatic Resources (2005)


Histology Facility of CNB

 

WEB and e-mail: histologia@cnb.csic.es

Tel. +34 91585-5349 / 4903


NEW WEB - EMMA PROJECT

Mouse Embryo Cryopreservation Facility of CNB

Spanish EMMA-INFRAFRONTIER node

 

WEB and e-mail: criocnb@cnb.csic.es

Tel. +34 91585-5349 / 4312


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Next TT meeting (TT2017)

14th Transgenic Technology Meeting
October 1-4, 2017 Salt Lake City, Utah, USA Snowbird Resort

Prague, Czech Republic, 20-23 March 2016



 

 Protocols for the generation and analysis of transgenic mice

 

Mendel: a simple excel workbook to compare the observed and expected distributions of genotypes/phenotypes in transgenic and knockout mouse crosses involving up to three unlinked loci by means of a χ(2) test. Transgenic Research 2012 Jun;21(3):677-810, Lluís Montoliu

Direct download of MENDEL Excel workbook

 

Laboratory protocols (restricted)

 

Advanced Protocols for Animals Transgenesis. An ISTT Manual

S. Pease & T. Saunders (Eds.) - Springer 2011

 


PhD Thesis

PhD thesis developed in Dr. Lluís Montoliu's laboratory


Database of transgenic mice, by Lluís Montoliu (2003)

 

Press here to request a free copy for academic-only use

 

 


 

Laboratory Manual:

"Generation of Transgenic Mice" by Lluís Montoliu (1997)

 

Press here to request a free copy for academic-only use

 

 


ALBA: asociacion de ayuda a personas con albinismo

Information on albinism

for scientists  and for persons with albinism

 

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Valencia, 5-6 April 2014


Albinismo. Una condición genética, dos realidades: España y Senegal


PROGRAMAS DE ACTIVIDADES DE I+D EN BIOMEDICINA, ENTRE GRUPOS DE INVESTIGACIÓN DE LA COMUNIDAD DE MADRID (Convocatoria 2010 - S2010/BMD-2439 - VISIONANIMAL-CM), 2012-2015

Coordinator: Lluis Montoliu. Participating groups: Jesús Cruces (UAM), Pedro de la Villa (UAH), Jaime Tejedor (Fund. Ramón y Cajal) y Anna González-Neira (CNIO)


 

 

 

Meetings, congresses, conferences and workshops organised and/or co-organised


Legislación Europea, Nacional y Autonómica sobre protección de los animales utilizados para la experimentacion y otros fines cientificos y sobre el uso de organismos modificados genéticamente


CSIC Bioethics Subcommission

CSIC

Serrano 113 (1st  floor)

28006 Madrid, Spain

Tel. 915681494

email: subcomitedebioetica@csic.es

 


 How to reach the CNB?

 

(Location of CNB at the Campus of the UAM) Pictures of CNB


Note: CNB is identified as building 18, Train Station is 27, Bus Stop is 28. Above is North. Madrid city is South.

Locate CNB with Google Maps



 


Updated: 24 January 2017

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