A C57BL/6 mouse

Genetic polymorphisms among C57BL/6 mouse inbred strains


Esther Zurita1,2, Mónica Chagoyen3, Marta Cantero1,2, Rosario Alonso4, Anna González-Neira4, Alejandro López-Jiménez6, José Antonio López-Moreno6, Carlisle P. Landel7, Javier Benítez2,4,5, Florencio Pazos3, Lluís Montoliu1,2,*

 1 Dep. Molecular and Cellular Biology and 3 Systems Biology Program, Centro Nacional de Biotecnología (CNB-CSIC), Campus de Cantoblanco, Darwin 3, 28049 Madrid, Spain

2 Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain

4 Human Genotyping-CEGEN Unit and 5 Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

6 Department of Psychobiology, Faculty of Psychology, Complutense University of Madrid, Spain

7 Transgenic and Gene Targeting Facility, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA


(*)Corresponding author:

Lluís Montoliu

Centro Nacional de Biotecnología (CNB-CSIC)

Campus de Cantoblanco, Darwin 3, 28049 Madrid (Spain)

tel.: +34915854844; fax.: +34915854506

E-mail: montoliu@cnb.csic.es

back to Lluis Montoliu's lab web page


Published in Transgenic Research

Transgenic Research

Zurita et al. (2010) epub: May 27, 2010


 The authors are most grateful to Thomas J. Fielder, Ulrich Märki, Johannes Wilbertz and Elizabeth Williams for their useful comments and suggestions and, especially, their generous contribution of DNA and/or tissue samples from several mouse strains used in this study.

C57BL/6 mouse inbred substrains considered in this analysis:

C57BL/6JArc from ARC, Perth, Australia

C57BL/6J from The Jackson Laboratory

C57BL/6J from Crl








JM8.N4 ES cells

SNP panel used: Illumina® Mouse Medium Density (MD) Linkage Mapping panel (1449 SNPs)

Illumina® Datasheet (PDF file)


Polymorphic SNPs useful to distinguish C57BL/6 substrains Chromosome:position (Build 37.1) C57BL/6JArc(ARC) C57BL/6J (Jax) C57BL/6J(Crl) C57BL6/JRccHsd(Harlan) C57BL/6JOlaHsd(Harlan) C57BL/6JBomTac(Taconic) B6(Cg)-Tyrc-2j/J(Jax) C57BL/6NCrl(Crl) C57BL/6NHsd(Harlan) C57BL/6NTac(Taconic) JM8.N4 ES cells
rs13477019 3 : 23723842 T T T A A A A A A A A
rs31233932 14 : 124508019 C C C C C C C T T T T
rs13480759 10 : 108815683 C C C C C C C T T T T
rs29359333 10 : 57864252 G G G G G G G A A A A
rs13483055 17 : 60459368 T T T C C C T C C C C
rs13481734 13 : 27129019 A A A G G G G G G G G
rs13480122 9 : 30964211 T T T T T T T C C C C
rs13479522 7 : 136179208 A A A A A A A G G G G
rs13478783 6 : 60541373 A A A A A A A G G G G
rs13480619 10 : 57472268 T T T T T T T C C C C
rs4165065 16 : 17412172 T T T T T T T C C C C
rs13481014 11 : 47930884 T T T T T T T C C C C


Raw Data: Excel file with the 1449 SNPs and all C57BL/6 substrains analyzed

Data submitted to:

SNP collection of Projects held at Mouse Phenome Database (MPD)

CNB1 SNPs (available)

dbSNP database (NCBI) (in process)

back to Lluis Montoliu's lab web page

Last update: May 31, 2010