ESPCR2006 Fritz Anders Memorial Lecture awarded to Manuel Serrano

Manuel Serrano's Lab at the Spanish National Cancer Research Centre

Selected publications by Manuel Serrano and his colleagues

(Update 15 September 2006)

(click onto each title to follow the corresponding Medline link)

Efeyan A, Garcia-Cao I, Herranz D, Velasco-Miguel S, Serrano M.
Tumour biology: Policing of oncogene activity by p53.
Nature. 2006 Sep 14;443(7108):159.

Efeyan A, Collado M, Velasco-Miguel S, Serrano M.
Genetic dissection of the role of p21(Cip1/Waf1) in p53-mediated tumour suppression.
Oncogene. 2006 Sep 11

Nieto M, Barradas M, Criado LM, Flores JM, Serrano M, Llano E.
Normal cellular senescence and cancer susceptibility in mice genetically deficient in Ras-induced senescence-1 (Ris1).
Oncogene. 2006 Sep 11

Garcia MA, Collado M, Munoz-Fontela C, Matheu A, Marcos-Villar L, Arroyo J, Esteban M, Serrano M, Rivas C.
Antiviral action of the tumor suppressor ARF.
EMBO J. 2006 Sep 7

Llanos S, Efeyan A, Monsech J, Dominguez O, Serrano M.

A High-Throughput Loss-of-Function Screening Identifies Novel p53 Regulators.
Cell Cycle. 2006 Aug 15;5(16)


Zeini M, Traves PG, Lopez-Fontal R, Pantoja C, Matheu A, Serrano M, Bosca L, Hortelano S.

Specific Contribution of p19ARF to Nitric Oxide-Dependent Apoptosis.
J Immunol. 2006 Sep 1;177(5):3327-36.


Gonzalez S, Serrano M.

A new mechanism of inactivation of the INK4/ARF locus.
Cell Cycle. 2006 Jul;5(13):1382-4.


Collado M, Serrano
The power and the promise of oncogene-induced senescence markers.
Nat Rev Cancer. 2006 Jun;6(6):472-6.

Gonzalez L, Freije JM, Cal S, Lopez-Otin C, Serrano M, Palmero I.
A functional link between the tumour suppressors ARF and p33ING1.
Oncogene. 2006 Apr 10

Garcia-Cao I, Garcia-Cao M, Tomas-Loba A, Martin-Caballero J, Flores JM, Klatt P, Blasco MA, Serrano M.
Increased p53 activity does not accelerate telomere-driven ageing.
EMBO Rep. 2006 May;7(5):546-52.

Gonzalez S, Klatt P, Delgado S, Conde E, Lopez-Rios F, Sanchez-Cespedes M, Mendez J, Antequera F, Serrano M.
Oncogenic activity of Cdc6 through repression of the INK4/ARF locus.
Nature. 2006 Mar 30;440(7084):702-6.

De la Cueva E, Garcia-Cao I, Herranz M, Lopez P, Garcia-Palencia P, Flores JM, Serrano M, Fernandez-Piqueras J, Martin-Caballero J.
Tumorigenic activity of p21(Waf1/Cip1) in thymic lymphoma.
Oncogene. 2006 Feb 6
 

Collado M, Serrano M.
The senescent side of tumor suppression.
Cell Cycle. 2005 Dec;4(12):1722-4.

Matheu A, Klatt P, Serrano M.
Regulation of the INK4A/ARF locus by HDAC inhibitors.
J Biol Chem. 2005 Oct 26

Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, Benguria A, Zaballos A, Flores JM, Barbacid M, Beach D, Serrano M.
Tumour biology: senescence in premalignant tumours.
Nature. 2005 Aug 4;436(7051):642.

Garcia-Cao I, Duran A, Collado M, Carrascosa MJ, Martin-Caballero J, Flores JM, Diaz-Meco MT, Moscat J, Serrano M.
Tumour-suppression activity of the proapoptotic regulator Par4.
EMBO Rep. 2005 Jun;6(6):577-83.

Pantoja C, de Los Rios L, Matheu A, Antequera F, Serrano M.
Inactivation of imprinted genes induced by cellular stress and tumorigenesis.
Cancer Res. 2005 Jan 1;65(1):26-33.

Matheu A, Pantoja C, Efeyan A, Criado LM, Martin-Caballero J, Flores JM, Klatt P, Serrano M.
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.
Genes Dev. 2004 Nov 15;18(22):2736-46.

Martin-Caballero J, Flores JM, Garcia-Palencia P, Collado M, Serrano M.
Different cooperating effect of p21 or p27 deficiency in combination with INK4a/ARF deletion in mice.
Oncogene. 2004 Oct 28;23(50):8231-7.

Nieto M, Samper E, Fraga MF, Gonzalez de Buitrago G, Esteller M, Serrano M.
The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine.
Oncogene. 2004 Jan 22;23(3):735-43.

Klatt P, Serrano M.
Engineering cancer resistance in mice.
Carcinogenesis. 2003 May;24(5):817-26.

Garcia-Cao I, Garcia-Cao M, Martin-Caballero J, Criado LM, Klatt P, Flores JM, Weill JC, Blasco MA, Serrano M.
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally.
EMBO J. 2002 Nov 15;21(22):6225-35.

Palmero I, Murga M, Zubiaga A, Serrano M.
Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2.
Oncogene. 2002 May 2;21(19):2939-47.

Barradas M, Gonos ES, Zebedee Z, Kolettas E, Petropoulou C, Delgado MD, Leon J, Hara E, Serrano M.
Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence.
Exp Cell Res. 2002 Feb 15;273(2):127-37.

Serrano M, Blasco MA.
Putting the stress on senescence.
Curr Opin Cell Biol. 2001 Dec;13(6):748-53.

Martin-Caballero J, Flores JM, Garcia-Palencia P, Serrano M.
Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.
Cancer Res. 2001 Aug 15;61(16):6234-8.

Serrano M, Massague J.
Networks of tumor suppressors. Workshop: tumor suppressor networks.
EMBO Rep. 2000 Aug;1(2):115-9.

Serrano M.
The INK4a/ARF locus in murine tumorigenesis.
Carcinogenesis. 2000 May;21(5):865-9.

Pantoja C, Serrano M.
Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.
Oncogene. 1999 Sep 2;18(35):4974-82.

Herranz M, Santos J, Salido E, Fernandez-Piqueras J, Serrano M.
Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas.
Cancer Res. 1999 May 1;59(9):2068-71.

Palmero I, Pantoja C, Serrano M.
p19ARF links the tumour suppressor p53 to Ras.
Nature. 1998 Sep 10;395(6698):125-6.

Serrano M.
The tumor suppressor protein p16INK4a.
Exp Cell Res. 1997 Nov 25;237(1):7-13.

Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW.
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
Cell. 1997 Mar 7;88(5):593-602.

Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA.
Role of the INK4a locus in tumor suppression and cell mortality.
Cell. 1996 Apr 5;85(1):27-37.

Serrano M, Gomez-Lahoz E, DePinho RA, Beach D, Bar-Sagi D.
Inhibition of ras-induced proliferation and cellular transformation by p16INK4.
Science. 1995 Jan 13;267(5195):249-52.

Serrano M, Hannon GJ, Beach D.
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Nature. 1993 Dec 16;366(6456):704-7.