DIINOCELL in Horizon Magazine


Benedict O'Donnell has interviewed DIVINOCELL participants for Horizon, the EU Research and Innovation Magazine. The article appeared on-line on 11 July 2014. Quoting Joen Luirink, DIVINOCELL results  "are exciting results ... but the work to turn them into drugs is only just beginning"


DIVINOCELL investigator gains Marie Curie fellowship at Newcastle


The Newcastle University is receiving a Marie Curie fellowship (FP7-PEOPLE-2013-IEF) to incorporate Manuel Pazos to the group of Waldemar Vollmer. The research project, "Assembly and coordination of peptidoglycan synthesis complexes during bacterial growth and cell division" will run for 24 months and was officially approved on 17 February 2014. 

Manuel, who obtained his doctoral degree in the laboratory of MIguel Vicente at the CNB-CSIC, moved to Newcastle at the beginning of April. He briefly describes his newly started work for us:

"To gain new molecular insights into how the Escherichia coli wall grows during the cell cycle I will investigate the proteins and protein interactions of the core complexes (elongasome and septosome) involved in the synthesis of peptidoglycan (PG). I will first study the in vivo hierarchy of known and new protein interactions and their relationship with the PG synthesis machinery. Then I will study the PG-protein interactions and the enzymatic activities involved in the intermediate step between elongation and cell division. The results will show how the elongasome and septosome complexes are connected and regulated during the cell cycle. Finally, I will reconstruct the elongasome and septosome complexes under conditions resembling their natural environment to verify and quantify the activities of their assembled components."

The training of young scientists who can contribute to the expertise of the participant laboratories is among the most satisfying outcomes of DIVINOCELL. We congratulate Manuel and Waldemar for this excellent opportunity to work together.  



Interview and article at Youris


Marta Espar has published an article referring to DIVINOCELL. It can be read at:

1. Article: http://www.youris.com/Health/Antibiotics/Targeting-Bacterial-Cell-Division-To-Fight-Antibiotic-Resistance.kl 

The article is based on an interview to Miguel Vicente, Divinocell coordinator. The interview is at: 

2. Interview: http://www.youris.com/Health/Antibiotics/Miguel-Vicente---Blocking-Bacterial-Proliferation-Could-Overcome-Antibiotic-Resistance.kl


Miguel Vicente

EU-LAC Health - Linking European and Latin American-Caribbean policy making institutions in the field of health research


EU-LAC Health’s main objective is to define a detailed roadmap to guide policy-makers and other stakeholders to an intensification of the bi-regional collaboration between the Europe (EU), Latin America and the Caribbean (CELAC) in the area of health research. This consensus roadmap will be developed using a policy-oriented approach and taking into account the new political framework for EU-LAC collaboration in Science and Technology, in particular the EU-CELAC-JIRI (European Union – Community of Latin-American and Caribbean States Joint Initiative for Research and Innovation). The roadmap’s aim is to provide new insights on how to best coordinate and fund excellent cooperative health research between the two regions. EU-LAC HEALTH is a five-year project, financed by the European Union within the 7th Framework Programme (FP7). Read more in the link below. 

Vera Kammann

DIVINOCELL @ Microbichitos (EL PAIS)


Work done in collaboration between two DIVINOCELL beneficiaries, the CSIC group led by Miguel Vicente, and Biomol-Informatics has been referred in a blog, microbichitos, published by the spanish national newspaper EL PAÍS.


DIVINOCELL has been invited to submit comments on JPIAMR strategic research agenda.


The Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) aim is to coordinate research to combat the threat of rising antimicrobial resistance. The initiative, supported by the European Commission is directed  to coordinate the national research efforts of European Member States, Associated countries and third countries. The JPIAMR has drafted a strategic research agenda encompassing the research needs that are required. Currently this document is undergoing a public consultation. Professor MIguel Vicente, as coordinator of DIVINOCELL, has been asked by the Commission to submit comments on this document.


UChile in CNN Chile


Prof. Octavio Monastero, from the Universidad de Chile, appears in the CNN Chile program "Cápsula científica" where he talks about function and structure of the proteins, and his investigations under DIVINOCELL.

You can find the interview in Youtube in the link below (in Spanish).

Last DIVINOCELL annual meeting at Hotel Mercure Fontainebleau, Fontainebleau (France)


Organised by Veronique Arluison, from CNRS, France, the Last DIVINOCELL Annual Meeting was held at Hotel Mercure Fontainebleau, Fontainebleau, France, from 27 to 28 June 2013.

28 scientists from the 11 project partners participated in this meeting. A total of 20 scientific talks reviewed the progress achieved since the third annual meeting (Copenhagen, 2012). A special session dealt with the administrative and coordination tasks of the project.


A Specific Role for the ZipA Protein in Cell Division: STABILIZATION OF THE FtsZ PROTEIN.


A new role for a proto-ring component. Upon the discovery of FtsA*, a gain-of-function mutant of the FtsA protein that made the presence of ZipA dispensable for FtsZ binding to the membrane and for divisome assembly, the role of ZipA in Escherichia coli division was deemed to be subsidiary. However, work done by DIVINOCELL CSIC members at the Spanish Centro Nacional de Biotecnología shows that ZipA protects FtsZ from degradation by the ClpXP protease complex by rendering the FtsZ site that interacts with ClpX unavailable to the complex. As this protective role cannot be played by either FtsA or FtsA*, ZipA is likely to have at least one unique function in the stability of the proto-ring. These results are helping to delineate the minimal functions required for septation and will be applied to design the minimum structures needed to effect septation in E. coli.

The 2011 European Escherichia coli O104:H4 outbreak revisited


In response to the 2011 European health alert caused by a pathogenic Escherichia coli O104:H4 outbreak, the European Academy of Microbiology (EAM), established by the Federation of European Microbiological Societies (FEMS), convened a meeting in Paris on November 30th, 2011 on "EHEC infection and control" attended by world renowed experts in pathogenic E. coli. The major aims of this group were to review the scientific issues raised by the outbreak, to assess the handling of the crisis at the scientific and political levels, and to propose future actions. Several conclusions, which will have impact on future potential E. coli outbreaks, are outlined in a "perspectives" paper published in EMBO Molecular Medicine. The publication has been coordinated by the coordinator of DIVINOCELL, Miguel Vicente, who is also responsible for writing the initial text and assembling the final version.

Helge Karch, Erick Denamur, Ulrich Dobrindt, B. Brett Finlay, Regine Hengge, Ludgers Johannes,  Eliora Z. Ron, Tone Tønjum, Philippe J. Sansonetti and Miguel Vicente. 2012. The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak. EMBO Mol. Med.4: 1-8.