Mision & Vision of our group

Antagonist Modulator of Downstrem Regulatory Elements (DREAM) is a calcium-dependent multi-task protein mainly found in neurons that is involved in neurodegenerative disorders with high prevalence in humans, such as Alzheimer and Huntington.
Previous results from our group showed that DREAM interacts with a number of proteins within cells and suggested that DREAM function and localization may be regulated through protein-protein interaction. We also evidenced that DREAM shuttles to the nucleus of differentiated neurons, binding to the specific DNA motifs termed DRE-elements and eventually repressing gene transcription.
We are currently focused on the screening of DREAM interactome (protein-protein interactions -PDIs- and protein-DNA interactions -PDIs-). To achieve this aim we settled platform combining experimental large-scale appraches (protein arrays, antibody arrays and DNA arrays) and bioinformatic analysis of larga amounts of data.

Lab. Prof. José Ramón Naranjo

Alzheimer and neuronal disease laboratory.

Spanish National Biotechnology Centre (CNB-CSIC).
Darwin 3, Campus de Cantoblanco, 28049 Madrid, Spain.
Phone (office): +34 915854682 Phone (lab) +34 915854913
Fax: +34 915854506

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Download 5-year publications pdf list of 5-year publications









Group members

Senior Researchers:
Dr. Jose R. Naranjo

Dr. Britt Mellström


Dr. Juan Casado-Vela
View Juan Casado-Vela's profile on LinkedIn

Previous publications

CORDIS profile

Paz Gonzalez / Jose Dopazo

Bachelor studens:

Javier Morón

Elena Higeras

Lab news

  • OPEN ACCESS Novel bio-informatic platform for protein-protein interactions.
Campus map Full list of human proteins
How to get here... Full list of human genes
facebooktwitterlink youtube Lab data repository




Our lab is financed by JAE-Doc Grants «Junta para la Ampliación de Estudios» and co-financed by the European Social Fund.

Featured collaborators and companies
Logo Era-net neuron Logo Comunidad de Madrid NeuroNe network of excellence  F ondo Social Europeo  
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Webmaster: (jcasado@cnb.csic.es) Last update: Feb 2014