Lab. Dr. Lluís Montoliu
Tel. +34 915854844 (office) / Tel. +34 915854530
(lab.)
Fax. +34 915854506
La generación y análisis de modelos
animales de enfermedades humanas mediante ratones transgénicos y
mutantes junto con el estudio de los mecanismos de regulación de
expresión génica en mamíferos.
The generation and analysis
of transgenic and knockout mouse animal models of human diseases and the
study of regulation mechanisms of mammalian gene expression.
Lluís
Montoliu José
Victoria Tovar
Herrador
Julio Pozueta
Larios
Ángel
García Díaz
Marta Cantero
González
Julia Fernández
Ponzano
Juan José
Lazcano Duque
Esther Zurita
Redondo
Servicio de Histologia / Histology
Facility
Soledad Montalbán
Iglesias
Group of Dr.
Marta Nieto
Marta Nieto
López
Álvaro
Sebastian Serrano
Beatriz Cubelos
Álvarez
Publicaciones recientes / Recent Publications:
Lavado A., Jeffery G., Tovar V., de la Villa P.,
Montoliu L. (2006)
Ectopic
expression of tyrosine hydroxylase in the pigmented epithelium rescues
the retinal abnormalities and visual function common in albinos in the
absence of melanin
Journal of Neurochemistry 96(4):1201-11
Lavado A., Montoliu L. (2006)
New
animal models to study the role of tyrosinase in normal retinal development
Frontiers in Bioscience 11:743-752
Devinoy E., Montoliu L., Baranyi M., Thépot
D., Hiripi L., Fontaine M.L., Bodrogi L., Bosze Z. (2005)
Analysis
of the efficiency of the rabbit whey acidic protein gene 5' flanking region
in controlling the expression of homologous and heterologous linked genes
Journal of Dairy Research 72(S1):113-119
Lavado A., Matheu A., Serrano M., Montoliu L. (2005)
A
strategy to study tyrosinase transgenes in mouse melanocytes
BMC Cell Biology 6(1):18
Giménez E., Lavado A., Jeffery G., Montoliu
L. (2005)
Regional
abnormalities in retinal development are associated with local ocular hypopigmentation
Journal of Comparative Neurology 485: 338-347
Cendán C.M., Pujalte J.M., Portillo-Salido
E., Montoliu L., Baeyens J.M. (2005)
Formalin-induced
pain is reduced in s1 receptor knockout mice
European Journal of Pharmacology 511(1): 73-74.
Lavado A., Olivares C., Garcia-Borron JC, Montoliu
L. (2005)
Molecular
basis of the extreme dilution mottled mouse mutation: A combination of
coding and non-coding genomic alterations
Journal of Biological Chemistry 280(6):4817-24.
Epub 2004 Nov 30.
Montoliu L. (2004)
5th
Transgenic Technology meeting (http://www.imbim.uu.se/transtech)
Transgenic Research 13: 605-606.
Moreira PN, Giraldo P, Cozar P., Pozueta J., Jiménez
A., Montoliu L.*, Gutiérrez-Adán A.* (2004)
Efficient
generation of transgenic mice with intact yeast artificial chromosomes
by ICSI
Biology of Reproduction 71(6):1943-1947.
Giménez E., Lavado A., Giraldo P., Cozar
P., Jeffery G., Montoliu L. (2004)
A
transgenic mouse model with inducible tyrosinase gene expression using
the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic
projections found in albinism
Pigment Cell Research 17(4): 363-370.
Montoliu L., Larue L., Beermann F. (2004)
On
the Use of Regulatory Regions from Pigmentary Genes to Drive the Expression
of Transgenes in Mice
Pigment Cell Research 17: 188-190.
Regales L., Giraldo P., García-Díaz
A., Lavado A., Montoliu L. (2003)
Identification
and functional validation of a 5’ upstream regulatory sequence in the human
tyrosinase gene homologous to the Locus Control Region of the mouse tyrosinase
gene
Pigment Cell Research 16: 685-692.
Langa F., Codony X., Tovar V., Lavado A., Giménez
E., Cozar P., Cantero M., Dordal A., Hernández E., Pérez
R., Monroy X., Zamanillo D., Guitart X., Montoliu L. (2003)
Generation
and phenotypic analysis of sigma receptor type I (s1) knockout mice
European Journal of Neuroscience 18(8): 2188-2196.
Giménez E., Lavado A., Giraldo P., Montoliu
L. (2003)
Tyrosinase
gene expression is not detected in mouse brain outside the retinal pigment
epithelium cells
European Journal of Neuroscience 18(9): 2673-2676.
Giraldo P., Martínez A., Regales L., Lavado
A., García-Díaz A., Alonso A., Busturia A., Montoliu L. (2003)
Functional
dissection of the mouse tyrosinase locus control region indentifies a new
putative boundary activity.
Nucleic Acids Research 31(21): 6290-6305.
Montoliu L. (2003)
Manipulating
the mouse embryo: easier than ever!
Transgenic Research 12: 635-636.
Giraldo P., Rival-Gervier S., Houdebine L.M. &
Montoliu L. (2003)
The
potential benefits of insulators on heterologous constructs in transgenic
animals
Transgenic Research 12: 751-755.
Montoliu L. (2003)
Simple
databases to monitor the generation and organisation of transgenic mouse
colonies
Transgenic Research 12: 251-253.
Millot B., Montoliu L., Fontaine M.L., Mata
T. & Devinoy E. (2003)
Hormone
induced modifications of the chromatin structure surrounding 5´ upstream
regulatory regions conserved between the mouse and rabbit WAP genes.
Biochemical Journal 372(1): 41-52.
Full list of publications available at the Lab WEB page