Departamento
de Biología Molecular y Celular
Department
of Molecular and Cellular Biology
CNB-CSIC
Dr. Marta Nieto
Tel. +34 915854913
Fax. +34 915854506
Laboratory
WEB page
Objetivos / Aims
Diferenciación neural en la corteza cerebral.
Función de los factores de transcripción Cux-1 y Cux-2 en
la especificación de tipos neuronales. Analisis de ratones deficientes
en Cux-1/-2 (ko). Implicaciones en enfermedades neurodegenerativas.
Neural differentiation in
cerebral cortex. Function of Cux-1 an Cux-2 transcription factors in neuronal
type specification. Analysis of Cux-1/-2 knockout mice. Implications in
neurodegenerative diseases.
Personal / Staff
Marta Nieto
López
Alvaro Sebastian
Serrano
Beatriz Cubelos
Álvarez
Publicaciones recientes / Recent
Publications:
Imitola J, Raddassi K, Park KI, Mueller FJ, Nieto
M, Teng YD, Frenkel D, Li J, Sidman RL, Walsh CA, Snyder EY, Khoury SJ.
(2004)
Directed
migration of neural stem cells to sites of CNS injury by the stromal cell-derived
factor 1alpha/CXC chemokine receptor 4 pathway.
Proceedings of the National Academy of Sciences
U S A. 101(52):18117-22.
Nieto M, Monuki ES, Tang H, Imitola J, Haubst N,
Khoury SJ, Cunningham J, Gotz M, Walsh CA.(2004)
Expression
of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of
the cerebral cortex.
Journal of Comparative Neurology 479(2):168-80.
Mattar P, Britz O, Johannes C, Nieto M, Ma L, Rebeyka
A, Klenin N, Polleux F, Guillemot F, Schuurmans C. (2004)
A
screen for downstream effectors of Neurogenin2 in the embryonic neocortex.
Developental Biology 273(2):373-89.
Schuurmans C, Armant O, Nieto M, Stenman JM, Britz
O, Klenin N, Brown C, Langevin LM, Seibt J, Tang H, Cunningham JM, Dyck
R, Walsh C, Campbell K, Polleux F, Guillemot F.(2004)
Sequential
phases of cortical specification involve Neurogenin-dependent and -independent
pathways.
EMBO Journal 23(14):2892-902.
Nieto M, Schuurmans C, Britz O, Guillemot F. (2001)
Neural
bHLH genes control the neuronal versus glial fate decision in cortical
progenitors.
Neuron 29(2):401-13.
Last update:
13 January 2006
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