Departamento de Biología Molecular y Celular
Department of Molecular and Cellular Biology

Lab. Dr. Dolores Rodríguez

Tel. +34 915854549 (office) / Tel. +34 915855444 (lab.)
Fax. +34 915854506

Laboratory WEB page

Objetivos / Aims
El estudio de la biología molecular de torovirus y el desarrollo de herramientas diagnósticas para la identificación de este virus como agente causal de gastroenteritis en humanos y en animales.
The study of the molecular biology of toroviruses and the development of diagnostic tools for the identification of this virus as causing agent of gastroenteritis in humans and animals.

Memoria Científica 2003-2004

Research Summary 2003-2004

Personal / Staff

Dolores Rodríguez Aguirre
Soledad Blanco Chapinal
Ana Garzón Gutiérrez
Ana Maria Maestre Merens
Jaime Pignatelli Garrigós

Publicaciones recientes / Recent Publications:

Bárcena, M., Möbius, W., Schleich, S., Esteban, M., Rodriguez, D., Geerts, W.J.C., Koster, A.J. Griffiths, G. and Krijnse Locker, J. (2005)
"A vaccinia virus lacking A10L: viral core proteins accumulate on structures derived from the endoplasmic reticulum" Cellular Microbiology (in press)

Garzón, A., Maestre, A., Pignatelli, J., Rejas, M.T., Rodríguez, D. (2005)
"New insights on the structure and morphogenesis of Berne virus". The Nidovirus: The control of SARS and other Nidovirus diseases Pelman, S. and Holmes, K. Springer. (in press)

Abaitua F, Rodriguez JR, Garzon A, Rodriguez D, Esteban M. (2005)
Improving recombinant MVA immune responses: Potentiation of the immune responses to HIV-1 with MVA and DNA vectors expressing Env and the cytokines IL-12 and IFN-gamma.
Virus Res Oct 5; [Epub ahead of print]

Gonzalez B, Reina R, Garcia I, Andres S, Glaria I, Alzueta M, Mora MI, Jugo BM, Arrieta-Aguirre I, de la Lastra JM, Rodriguez D, Rodriguez JR, Esteban M, Grillo MJ, Blacklaws BA, Harkiss GD, Chebloune Y, Lujan L, de
Andres D, Amorena B. (2005)
Mucosal immunization of sheep with a Maedi-Visna virus (MVV) env DNA vaccine protects against early MVV productive infection.
Vaccine Jul 29;23(34):4342-52.

Gomez CE, Abaitua F, Rodriguez D, Esteban M. (2004)
Efficient CD8+ T cell response to the HIV-env V3 loop epitope from multiple virus isolates by a DNA prime/vaccinia virus boost (rWR and rMVA strains) immunization regime and enhancement by the cytokine IFN-gamma.
Virus Research 105(1):11-22.

Gallego-Gomez JC, Risco C, Rodriguez D, Cabezas P, Guerra S, Carrascosa JL, Esteban M. (2003)
Differences in virus-induced cell morphology and in virus maturation between MVA and other strains (WR, Ankara, and NYCBH) of vaccinia virus in infected human cells.
Journal of Virology 77(19):10606-10622.

Gonzalez-Aseguinolaza G, Nakaya Y, Molano A, Dy E, Esteban M, Rodriguez D, Rodriguez JR, Palese P, Garcia-Sastre A, Nussenzweig RS. (2003)
Induction of protective immunity against malaria by priming-boosting immunization with recombinant cold-adapted influenza and modified vaccinia Ankara viruses expressing a CD8+-T-cell epitope derived from the circumsporozoite protein of Plasmodium yoelii.
Journal of Virology 77(21):11859-11866.

Ramiro MJ, Zarate JJ, Hanke T, Rodriguez D, Rodriguez JR, Esteban M, Lucientes J, Castillo JA, Larraga V. (2003)
Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinant vectors expressing LACK.
Vaccine. 21(19-20):2474-2484.

Stein JV, Lopez-Fraga M, Abaitua F, Carvalho-Pinto CE, Rodriguez D, Gomez-Caro R, De Jong J, Martinez-A C, Medema JP, Hahne M. (2002)
APRIL modulates B and T cell immunity.
Journal of Clinical Investigation 109(12):1587-1598.

Sanchez AB, Rodriguez D, Garzon A, Amorena B, Esteban M, Rodriguez JR. (2002)
Visna/maedi virus Env protein expressed by a vaccinia virus recombinant induces cell-to-cell fusion in cells of different origins in the apparent absence of Env cleavage: role of glycosylation and of proteoglycans.
Archives of Virology 147(12):2377-2392.

Risco C, Rodriguez JR, Lopez-Iglesias C, Carrascosa JL, Esteban M, Rodriguez D. (2002)
Endoplasmic reticulum-Golgi intermediate compartment membranes and vimentin filaments participate in vaccinia virus assembly.
Journal of Virology 76(4):1839-1855.

Last update: 14 February 2006
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